Our daughter company RHEACELL is present at the following events:
2nd Münster Vascular Symposium on 25th March 2023 in Münster, Germany
29th Bonn Vein Days from 31st March to 1st of April 2023 in Bonn, Germany
52nd Meeting of the German Dermatological Society (DDG) from 26th to 29th of April 2023 in Berlin
DEWU German Wound Congress from 10th to 12th of May 2023 in Bremen, Germany
CVU-specific patient recruitment campaign site is online now.
Please visit: https://ulcus-cruris-studie.de/
National marketing authorization in Germany for novel cell therapy
Our daughter company RHEACELL has been granted national marketing authorization (§ 4b of the German Medicinal Products Act) in Germany for its cell therapy product AMESANAR®, produced by TICEBA, for the use in patients with chronic wounds.
Stem cell pioneer and expert - navigating hitherto uncharted waters
Drawing on over 15 years' experience in advanced stem cell research and regenerative medicine to pioneer the production of ABCB5-positive (ABCB5+) mesenchymal stem cells and innovative treatment pathways.
Using cutting-edge, in-house process technology and quality control systems to generate state-of-the-art ABCB5+ mesenchymal stem cells ("H.F.M Stem Cells") and ATMP (Advanced Therapy Medicinal Products) in line with AMG (German Medicinal Products Act) requirements.
Translational medicine: from in-house potency assay to clinical efficacy
Science-based mechanisms-of-action translated into GMP-validated potency assays and release criteria to predict clinical efficacy.
Off-the-shelf & ready to use: serving market needs
High through-put stem cell production based on globally patented technology and expertise - catering for world-wide market needs - anytime, anyplace, anywhere.
Clinical development pipeline and established technology platform focusing on rare diseases and more
Our tried and tested patented technology platform nurturing next-generation technologies (CRISPR/Cas, iPS Technology and 3D Bioprinting), heralding the arrival of next-generation cell therapies.
ABCB5 patents – a world-wide exclusive
TICEBA - exclusive licensee of the full ABCB5 patent portfolio from Boston Children's Hospital - a teaching affiliate of Harvard Medical School, Boston, Massachusetts. Several of these were invented at the same time and are jointly owned by TICEBA.
First ABCB5 patent
First description of ABCB5+ cells and creation of TICEBA
TICEBA launches business activities
Approval granted for tissue procurement and processing
Creation of RHEACELL
Manufacturing license granted (AMG – German Medicinal Products Act)
First clinical trial using ABCB5+ cells
Technology platform patent granted ("H.F.M Stem Cells")
National marketing authorization applied for in Germany
Pediatric Investigation Plan (PIP) approved by PDCO (EMA) for RHEACELL
National marketing authorization in Germany granted for AMESANAR®
A stringent quality control procedure is the hallmark of guaranteed product safety and quality in line with international GMP standards. Every product batch meets standardized, validated in-house release criteria.