Lexicon

A B C D E F G H I L M P Q R S T

ATop Pfeil

BTop Pfeil

CTop Pfeil

Cartilage

Cartilage tissue is a solid both compressive and bending elastic support avascular tissue, which also forms in the development of the system of the bony skeleton. It can be cut, and like the other connective- and supportive tissue forms consist of cells and the surrounding intercellular substance, which consists of shaped and unshaped components.


Cell isolation, cultivation and proliferation

Cell isolation means the separation of selected cells form a tissue or body fluid in the context of medical or research purposes. The different cell isolation procedures form the basis of cell biological research and technology. Depending on the source and target cell, a particular method of preparation, purification and separation is chosen. Children’s Hospital The Boston Children's Hospital is a children's hospital in the Longwood Medical and Academic Area (LMA) in Boston as well as a teaching hospital based in the LMA Harvard Medical School.


Children’s Hospital

The Boston Children's Hospital is a children's hospital in the Longwood Medical and Academic Area (LMA) in Boston as well as a teaching hospital based in the LMA Harvard Medical School.


Clean rooms

In order to meet the demanding stem cell treatment requirements, TICEBA has several cleanrooms of different cleanliness levels. These are connected together by special locks. The entire structure of the laboratories and the design of each workspace enable a smooth workflow as well as unobstructed material flow. This system makes efficient processing of your stem cells possible.


Cryoconservation

Cryopreservation refers to the storage of cells or tissues by freezing it in liquid nitrogen. Using this method, it is possible to maintain the vitality of the cells almost unlimited, although the biological system enters the state of aggregation of a solid. Cryopreservation can be applied to both, plant cells and in animal cells, in humans for example also in sperm, ova and embryos.


DTop Pfeil

ETop Pfeil

FTop Pfeil

GTop Pfeil

HTop Pfeil

ITop Pfeil

LTop Pfeil

MTop Pfeil

PTop Pfeil

Patents

TICEBA is exclusive licensee of the following patents:


USA

  • Frank MH and Sayegh MH; The Brigham and Women’s Hospital, Inc. "Gene encoding a multidrug-resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof." US Patent 6,846,883. 25. January 2005.
  • Frank MH; The Brigham and Women’s Hospital, Inc. "ABCB5 positive mesenchymal stem cells as immunmodulators." US Provisional Patent Application No.: 60/809,407. 31. May 2006.
  • Frank MH and Sayegh MH; The Brigham and Women’s Hospital, Inc. "Gene encoding a multidrug-resistance human P-glycoprotein homologue on chromosome 7p15-2 and uses thereof." US Patent 7,465,554. 16. December 2008.
  • Frank MH and Sayegh MH; The Brigham and Women’s Hospital, Inc. "Gene encoding a multidrug-resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof." US Patent 8,076,091. 13. December 2011.

Europe

  • Frank MH and Sayegh MH; The Brigham and Women’s Hospital, Inc. "A gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof." European Patent EP1290028. 01. December 2010.

Pluripotency

Pluripotent stem cells refer to cells, which possess the ability to differentiate into any cell type of an organism, as they are still set to any particular tissue type.


Progenitor cell

A progenitor cell is the progeny of a multi-potent adult stem cell or isolated from fetal tissue. On one hand it comprises in terms of their ability to regenerate stem cell properties, but on the other hand, it is set to a future functional area - however, this "definition" is still reversible. Progenitor cells are therefore sometimes referred to as determinate stem cells.


QTop Pfeil

RTop Pfeil

STop Pfeil

TTop Pfeil
News
Article about our study with limbal stem cells

On the website of the Harvard Stem Cell Institute you will find the following news release about the ongoing clinical trial conducted by our daughter company RHEACELL in patients suffering from limbal stem cell deficiency: Restoring vision: A stem cell therapy for cornea regeneration reaches the clinical-trial stage.

Clinical Trial - EB

The international phase I/IIa clinical trial has been approved by the U.S. Food and Drug Administration (FDA) and several European competent national regulatory authorities. The medicinal drug product tested in this trial has recently been granted Orphan Drug designation from the FDA and the European Medicines Agency (EMA) for the treatment of EB.

Clinical Trial - LSCD

The international phase I/IIa clinical trial has been approved by the U.S. Food and Drug Administration (FDA) and the German regulatory authority (Paul Ehrlich Institute). The medicinal drug product tested in this trial has recently been granted Orphan Drug designation from the FDA and the European Medicines Agency (EMA) and Fast Track designation from the FDA for the treatment of LSCD.

Safety

In a comprehensive preclinical study program, safety and local tolerability of ABCB5+ MSCs following subcutaneous, intramuscular and intravenous application has been demonstrated (Tappenbeck et al., 2019).

Newsletter